It is a very good animation that explains the HIV replication very clearly. For a free download of the video please visit my website rufusrajadurai.wetpaint.com and other 3D animation videos visit rufusrajadurai.wetpaint.com greetings Dr.Rufus the text of this video is here Targeting HIV replication The replication of HIV-1 is a multi-stage process. Each step is critical for the successful replication and is therefore a potential target of anti-retroviral drugs. Step one is the infection of asuitable host cells, such as a CD4-positive T-lymphocytes. Entry of HIV into the cell requires the presence of certain receptors on the cell surface, CD4 - receptors and co-receptors such as CCR5 or CXCR4. These receptors with protein complexes that are embedded in the viral envelope interact. an extracellular gp120 and a transmembrane gp 41 When HIV approaches the target cell gp120 binds to CD4 receptors: These complexes are composed of two glycoproteins. This process is calledFixing. It promotes further binding to a co-receptor. Co-receptor binding leads to a conformational change in gp120. This allows gp41 to unfold and insert its hydrophobic terminus into the cell membrane. Gp 41 then folds back on itself. This draws the virus to the cell and facilitates the fusion of their membranes. The viral nucleocapsid into the host cell and breaks releasing two viral RNA strands and 3 essential replication enzymes: Integrase, Protease and ReverseTranscriptase ...
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